蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书| Product Name: | FADD Recombinant Rabbit mAb |
| Cat No.: | RMA02831 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB, IHC, ICC/IF, FC, IP |
| Recommended Dilution: | WB, IHC, ICC/IF, FC, IP |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human FADD |
| Calculated Molecular Weight: | 23 kDa |
| Observed Molecular Weight: | 28 kDa |
| GenBank Accession Number: | Q13158 |
| Gene ID (NCBI): | 8772 |
| Synonyms: | GIG3; MORT1 |
| Background: | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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