蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3)
Cat#:TP06180应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | Phospho-STAT3 (Ser727) Recombinant Rabbit mAb |
| Cat No.: | RMA03076 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Rat |
| Tested Applications: | WB, IHC, ICC/IF |
| Recommended Dilution: | WB: 1:1000 IHC: 1:20 ICC/IF: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser727 of human STAT3 |
| Calculated Molecular Weight: | 88 kDa |
| Observed Molecular Weight: | 88 kDa |
| GenBank Accession Number: | P40763 |
| Gene ID (NCBI): | 6774 |
| Synonyms: | APRF; HIES; ADMIO; ADMIO1 |
| Background: | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015] |
| Category: | Primary Ab |
相关产品
