蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书| Product Name: | LC3A/B Rabbit pAb |
| Cat No.: | DPA01421 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB |
| Recommended Dilution: | WB: 1:1000 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 1 |
| Immunogen: | Synthetic peptide |
| Calculated Molecular Weight: | 14 kDa |
| Observed Molecular Weight: | 14,16 kDa |
| GenBank Accession Number: | Q9H492 Q9GZQ8 |
| Gene ID (NCBI): | 84557 81631 |
| Synonyms: | LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3; MAP1LC3A; LC3B; ATG8F; MAP1LC3B-a; MAP1A/1BLC3; MAP1LC3B |
| Background: | Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. |
| Category: | Primary Ab |
相关产品
