蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书PKR Rabbit pAb
Cat#:DPA04768应用：WB,ICC/IF,FC,IP
| Product Name: | PKR Rabbit pAb |
| Cat No.: | DPA04768 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,ICC/IF,FC,IP |
| Recommended Dilution: | WB: 1:1000 ICC/IF: 1:20 FC: 1:20 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of mouse PKR |
| Calculated Molecular Weight: | 62 kDa |
| Observed Molecular Weight: | 74 kDa |
| GenBank Accession Number: | Q03963 |
| Gene ID (NCBI): | 19106 |
| Synonyms: | Pkr; Tik; Prkr; AI467567; AI747578; 2310047A08Rik; 4732414G15Rik |
| Background: | IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. |
| Category: | Primary Ab |
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