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查看说明书Recombinant FK506 Binding Protein 4 (FKBP4)
Cat#:TP02137应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | FKBP52 Rabbit pAb |
| Cat No.: | DPA04939 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC,ICC/IF,FC |
| Recommended Dilution: | WB: 1:1000-1:5000 IHC: 1:50-1:200 ICC/IF: 1:20-1:50 FC: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human FKBP52 |
| Calculated Molecular Weight: | 52 kDa |
| Observed Molecular Weight: | 52 kDa |
| GenBank Accession Number: | Q02790 |
| Gene ID (NCBI): | 2288 |
| Synonyms: | HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase |
| Background: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008] |
| Category: | Primary Ab |
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