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查看说明书Presenilin 2 Rabbit pAb
Cat#:DPA05126应用：WB,IHC,ICC/IF,IP
| Product Name: | Presenilin 2 Rabbit pAb |
| Cat No.: | DPA05126 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC,ICC/IF,IP |
| Recommended Dilution: | WB: 1:2000 IHC: 1:20 ICC/IF: 1:20-1:50 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human Presenilin 2 |
| Calculated Molecular Weight: | 50 kDa |
| Observed Molecular Weight: | 23 kDa |
| GenBank Accession Number: | P49810 |
| Gene ID (NCBI): | 5664 |
| Synonyms: | AD4; PS2; AD3L; STM2; CMD1V |
| Background: | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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