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分子生物学
规格：
查看说明书Cyclin D1 Rabbit pAb
Cat#:DPA05254应用：WB,IHC,ICC/IF,IP
| Product Name: | Cyclin D1 Rabbit pAb |
| Cat No.: | DPA05254 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC,ICC/IF,IP |
| Recommended Dilution: | WB: 1:2000 IHC: 1:20-1:500 ICC/IF: 1:100 IP: 1:30 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human Cyclin D1 |
| Calculated Molecular Weight: | 34 kDa |
| Observed Molecular Weight: | 36 kDa |
| GenBank Accession Number: | P24385 |
| Gene ID (NCBI): | 595 |
| Synonyms: | BCL1; PRAD1; U21B31; D11S287E |
| Background: | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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