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规格：
查看说明书UHRF1 Rabbit pAb
Cat#:DPA05028应用：WB,IHC,ICC/IF,FC,IP
| Product Name: | UHRF1 Recombinant Rabbit mAb |
| Cat No.: | RMA01079 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC,ICC/IF,FC,IP |
| Recommended Dilution: | WB,IHC,ICC/IF,FC,IP |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of human UHRF1 |
| Calculated Molecular Weight: | 89 kDa |
| Observed Molecular Weight: | 97 kDa |
| GenBank Accession Number: | Q96T88 |
| Gene ID (NCBI): | 29128 |
| Synonyms: | Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95 |
| Background: | This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014] |
| Category: | Primary Ab |
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