蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书ATM Rabbit pAb
Cat#:DPA04048应用：WB,ICC/IF,FC,IP,ChIP
| Product Name: | ATM Recombinant Rabbit mAb |
| Cat No.: | RMA01119 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IHC,ICC/IF,FC |
| Recommended Dilution: | WB,IHC,ICC/IF,FC |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human ATM |
| Calculated Molecular Weight: | 351 kDa |
| Observed Molecular Weight: | 351 kDa |
| GenBank Accession Number: | Q13315 |
| Gene ID (NCBI): | 472 |
| Synonyms: | AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1 |
| Background: | The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010] |
| Category: | Primary Ab |
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