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Gemin 1 Recombinant Rabbit mAb

Cat No.: RMA01325
规格:
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  • Western blot analysis of Anti-Gemin 1 antibody(RMA01325) Gel: 15%SDS-PAGE Lysate: 20 μg Primary antibody: RMA01325(Gemin 1 antibody)at dilution 1:1000 Secondary antibody: Goat anti rabbit IgG (SPA10002)at 1:1000 dilution

Product Name: Gemin 1 Recombinant Rabbit mAb
Cat No.: RMA01325
Clonality: Monoclonal
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB,IHC,IP
Recommended Dilution: WB,IHC,IP
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: A synthetic peptide of human Gemin 1
Calculated Molecular Weight: 32 kDa
Observed Molecular Weight: 35 kDa
GenBank Accession Number: Q16637
Gene ID (NCBI): 6606
Synonyms: SMA; SMN; SMA1; SMA2; SMA3; SMA4; SMA@; SMNT; BCD541; GEMIN1; TDRD16A; T-BCD541
Background: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2014]
Category: Primary Ab
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