蛋白
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检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书G protein alpha 13 Rabbit pAb
Cat#:DPA04180应用：WB,IHC
| Product Name: | G protein alpha 13 Recombinant Rabbit mAb |
| Cat No.: | RMA01417 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC |
| Recommended Dilution: | WB,IHC |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human G protein alpha 13 |
| Calculated Molecular Weight: | 44 kDa |
| Observed Molecular Weight: | 44 kDa |
| GenBank Accession Number: | Q14344 |
| Gene ID (NCBI): | 10672 |
| Synonyms: | G13 |
| Background: | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). |
| Category: | Primary Ab |
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