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查看说明书Cellular Apoptosis Susceptibility Rabbit pAb
Cat#:DPA03458应用：WB,IHC,ICC/IF,FC
| Product Name: | Cellular Apoptosis Susceptibility Recombinant Rabbit mAb |
| Cat No.: | RMA01698 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB,IHC,ICC/IF,FC |
| Recommended Dilution: | WB,IHC,ICC/IF,FC |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human Cellular Apoptosis Susceptibility |
| Calculated Molecular Weight: | 110 kDa |
| Observed Molecular Weight: | 110 kDa |
| GenBank Accession Number: | P55060 |
| Gene ID (NCBI): | 1434 |
| Synonyms: | CAS; CSE1; XPO2 |
| Background: | Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] |
| Category: | Primary Ab |
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