蛋白
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检测试剂盒
蛋白MARKER
分子生物学
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查看说明书Recombinant Human DCAMKL1 / DCLK1 Protein
Cat#:TP08356应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | DCAMKL1 Recombinant Rabbit mAb |
| Cat No.: | RMA01914 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC,ICC/IF |
| Recommended Dilution: | WB,IHC,ICC/IF |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human DCAMKL1 |
| Calculated Molecular Weight: | 82 kDa |
| Observed Molecular Weight: | 82 kDa |
| GenBank Accession Number: | O15075 |
| Gene ID (NCBI): | 9201 |
| Synonyms: | CL1; DCLK; CLICK1; DCDC3A; DCAMKL1 |
| Background: | This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010] |
| Category: | Primary Ab |
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