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Proteasome beta 8 Recombinant Rabbit mAb

Cat No.: RMA02669
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  • Western blot analysis of Anti-Proteasome beta 8 antibody(RMA02669) Gel: 15%SDS-PAGE Lysate: 20 μg Primary antibody: RMA02669(Proteasome beta 8 antibody)at dilution 1:1000 Secondary antibody: Goat anti rabbit IgG (SPA10002)at 1:1000 dilution

Product Name: Proteasome beta 8 Recombinant Rabbit mAb
Cat No.: RMA02669
Clonality: Monoclonal
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB, IHC, ICC/IF, FC, IP
Recommended Dilution: WB, IHC, ICC/IF, FC, IP
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: A synthetic peptide of human LMP7
Calculated Molecular Weight: 30 kDa
Observed Molecular Weight: 23 kDa
GenBank Accession Number: P28062
Gene ID (NCBI): 5696
Synonyms: JMP; ALDD; LMP7; NKJO; D6S216; PSMB5i; RING10; D6S216E
Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008]
Category: Primary Ab
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