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HMGCR Recombinant Rabbit mAb

Cat No.: RMA02698
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  • Western blot analysis of Anti-HMGCR antibody(RMA02698) Gel: 6%SDS-PAGE Lysate: 20 μg Primary antibody: RMA02698(HMGCR antibody)at dilution 1:1000 Secondary antibody: Goat anti rabbit IgG (SPA10002)at 1:1000 dilution

Product Name: HMGCR Recombinant Rabbit mAb
Cat No.: RMA02698
Clonality: Monoclonal
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB, IP
Recommended Dilution: WB, IP
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: A synthetic peptide of human HMGCR
Calculated Molecular Weight: 98 kDa
Observed Molecular Weight: 98 kDa
GenBank Accession Number: P04035
Gene ID (NCBI): 3156
Synonyms: LDLCQ3
Background: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Category: Primary Ab
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