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查看说明书Recombinant Thioredoxin Reductase 1 (TXNRD1)
Cat#:TP04360应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | Thioredoxin Reductase 1 Recombinant Rabbit mAb |
| Cat No.: | RMA02711 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC, ICC/IF, FC, IP |
| Recommended Dilution: | WB, IHC, ICC/IF, FC, IP |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of human TXNRD1 |
| Calculated Molecular Weight: | 67 kDa |
| Observed Molecular Weight: | 55 kDa |
| GenBank Accession Number: | Q16881 |
| Gene ID (NCBI): | 7296 |
| Synonyms: | TR; TR1; TXNR; TRXR1; GRIM-12 |
| Background: | The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017] |
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