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DNA Ligase IV Recombinant Rabbit mAb

Cat No.: RMA02723
规格:
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  • Western blot analysis of Anti-DNA Ligase IV antibody(RMA02723) Gel: 6%SDS-PAGE Lysate: 20 μg Primary antibody: RMA02723(DNA Ligase IV antibody)at dilution 1:1000 Secondary antibody: Goat anti rabbit IgG (SPA10002)at 1:1000 dilution

Product Name: DNA Ligase IV Recombinant Rabbit mAb
Cat No.: RMA02723
Clonality: Monoclonal
Species Reactivity: Human
Tested Applications: WB, IHC, ICC/IF
Recommended Dilution: WB, IHC, ICC/IF
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: Recombinant protein of human DNA Ligase IV
Calculated Molecular Weight: 104 kDa
Observed Molecular Weight: 104 kDa
GenBank Accession Number: P49917
Gene ID (NCBI): 3981
Synonyms: LIG4S
Background: The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Category: Primary Ab
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