蛋白
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检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Recombinant Human ERCC1 Protein
Cat#:TP02041应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | ERCC1 Recombinant Rabbit mAb |
| Cat No.: | RMA02735 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB, IHC, ICC/IF, FC |
| Recommended Dilution: | WB, IHC, ICC/IF, FC |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human ERCC1 |
| Calculated Molecular Weight: | 33 kDa |
| Observed Molecular Weight: | 39 kDa |
| GenBank Accession Number: | P07992 |
| Gene ID (NCBI): | 2067 |
| Synonyms: | UV20; COFS4; RAD10 |
| Background: | The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009] |
| Category: | Primary Ab |
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