蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Rb Rabbit pAb
Cat#:DPA01254应用：WB,IHC,ICC/IF,FC,IP
| Product Name: | Rb Recombinant Rabbit mAb |
| Cat No.: | RMA02796 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB, IHC, ICC/IF, FC, IP |
| Recommended Dilution: | WB, IHC, ICC/IF, FC, IP |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of mouse Rb |
| Calculated Molecular Weight: | 106 kDa |
| Observed Molecular Weight: | 106 kDa |
| GenBank Accession Number: | P13405 |
| Gene ID (NCBI): | 19645 |
| Synonyms: | Rb; pRb; Rb-1 |
| Background: | Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). |
| Category: | Primary Ab |
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