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查看说明书Recombinant Thymidylate Synthetase (TYMS)
Cat#:TP04363应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | Thymidylate Synthase Recombinant Rabbit mAb |
| Cat No.: | RMA02816 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC, ICC/IF, FC, IP |
| Recommended Dilution: | WB, IHC, ICC/IF, FC, IP |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human Thymidylate Synthase |
| Calculated Molecular Weight: | 36 kDa |
| Observed Molecular Weight: | 36 kDa |
| GenBank Accession Number: | P04818 |
| Gene ID (NCBI): | 7298 |
| Synonyms: | TS; TMS; HST422 |
| Background: | Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017] |
| Category: | Primary Ab |
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