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E2F4 Recombinant Rabbit mAb

Cat No.: RMA02819
规格:
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  • Western blot analysis of Anti-E2F4 antibody(RMA02819) Gel: 10% SDS-PAGE Lysate: 20 μg Primary antibody: RMA02819(E2F4 antibody)at dilution 1:1000 Secondary antibody: Goat anti rabbit IgG (SPA10002)at 1:1000 dilution

Product Name: E2F4 Recombinant Rabbit mAb
Cat No.: RMA02819
Clonality: Monoclonal
Species Reactivity: Human
Tested Applications: WB, IHC, ICC/IF, FC
Recommended Dilution: WB, IHC, ICC/IF, FC
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: A synthetic peptide of human E2F4
Calculated Molecular Weight: 44 kDa
Observed Molecular Weight: 65 kDa
GenBank Accession Number: Q16254
Gene ID (NCBI): 1874
Synonyms: E2F-4
Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
Category: Primary Ab
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