蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书ROCK1 Rabbit pAb
Cat#:DPA01317应用：WB,IHC,ICC/IF,FC,IP
| Product Name: | ROCK1 Recombinant Rabbit mAb |
| Cat No.: | RMA02845 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC, ICC/IF, FC, IP |
| Recommended Dilution: | WB, IHC, ICC/IF, FC, IP |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human ROCK1 |
| Calculated Molecular Weight: | 158 kDa |
| Observed Molecular Weight: | 158 kDa |
| GenBank Accession Number: | Q13464 |
| Gene ID (NCBI): | 6093 |
| Synonyms: | ROCK-I; P160ROCK |
| Background: | This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015] |
| Category: | Primary Ab |
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