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查看说明书Recombinant Human PABPN1 Protein
Cat#:TP03281应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | PABPN1 Recombinant Rabbit mAb |
| Cat No.: | RMA02862 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB, IHC, ICC/IF, FC, IP |
| Recommended Dilution: | WB, IHC, ICC/IF, FC, IP |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human PABPN1 |
| Calculated Molecular Weight: | 33 kDa |
| Observed Molecular Weight: | 50 kDa |
| GenBank Accession Number: | Q86U42 |
| Gene ID (NCBI): | 8106 |
| Synonyms: | OPMD; PAB2; PABII; PABP2; PABP-2 |
| Background: | This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010] |
| Category: | Primary Ab |
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