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ASK1 Recombinant Rabbit mAb

Cat No.: RMA02864
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  • Western blot analysis of Anti-ASK1 antibody(RMA02864) Gel: 6%SDS-PAGE Lysate: 20 μg Primary antibody: RMA02864(ASK1 antibody)at dilution 1:1000 Secondary antibody: Goat anti rabbit IgG (SPA10002)at 1:1000 dilution

Product Name: ASK1 Recombinant Rabbit mAb
Cat No.: RMA02864
Clonality: Monoclonal
Species Reactivity: Human, Mouse
Tested Applications: WB, IHC, ICC/IF, FC
Recommended Dilution: WB, IHC, ICC/IF, FC
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: A synthetic peptide of human ASK1
Calculated Molecular Weight: 155 kDa
Observed Molecular Weight: 155 kDa
GenBank Accession Number: Q99683
Gene ID (NCBI): 4217
Synonyms: ASK1; MEKK5; MAPKKK5
Background: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
Category: Primary Ab
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