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查看说明书Recombinant Mitogen Activated Protein Kinase Kinase 3 (MAP2K3)
Cat#:TP02897应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | MEK3 Recombinant Rabbit mAb |
| Cat No.: | RMA02870 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC, ICC/IF, FC, IP |
| Recommended Dilution: | WB, IHC, ICC/IF, FC, IP |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of human MEK3 |
| Calculated Molecular Weight: | 39 kDa |
| Observed Molecular Weight: | 38-40 kDa |
| GenBank Accession Number: | P46734 |
| Gene ID (NCBI): | 5606 |
| Synonyms: | MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2 |
| Background: | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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