蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Factor XIIIa Rabbit pAb
Cat#:DPA01393应用：WB,IHC,ICC/IF,FC
| Product Name: | Factor XIIIa Recombinant Rabbit mAb |
| Cat No.: | RMA02900 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB, IHC, ICC/IF, FC |
| Recommended Dilution: | WB, IHC, ICC/IF, FC |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of human Factor XIIIa |
| Calculated Molecular Weight: | 83 kDa |
| Observed Molecular Weight: | 83 kDa |
| GenBank Accession Number: | P00488 |
| Gene ID (NCBI): | 2162 |
| Synonyms: | F13A |
| Background: | This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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