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分子生物学
规格：
查看说明书Raf1 Rabbit pAb
Cat#:DPA03403应用：WB,IHC,ICC/IF
| Product Name: | Phospho-Raf1 (Ser259) Rabbit pAb |
| Cat No.: | DPA05330 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC |
| Recommended Dilution: | WB: 1:1000 IHC: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser259 of human Raf1 |
| Calculated Molecular Weight: | 73 kDa |
| Observed Molecular Weight: | 73 kDa |
| GenBank Accession Number: | P04049 |
| Gene ID (NCBI): | 5894 |
| Synonyms: | NS5; CRAF; Raf-1; c-Raf; CMD1NN |
| Background: | This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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