蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书CBL Rabbit pAb
Cat#:DPA02541应用：WB,ICC/IF,FC,IP
| Product Name: | Phospho-CBL (Tyr731) Rabbit pAb |
| Cat No.: | DPA05375 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IP |
| Recommended Dilution: | WB: 1:1000 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Tyr731 of human CBL |
| Calculated Molecular Weight: | 100 kDa |
| Observed Molecular Weight: | 120 kDa |
| GenBank Accession Number: | P22681 |
| Gene ID (NCBI): | 867 |
| Synonyms: | CBL2; NSLL; C-CBL; RNF55; FRA11B |
| Background: | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016] |
| Category: | Primary Ab |
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