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检测试剂盒
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分子生物学
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查看说明书Recombinant Breast Cancer Anti-Estrogen Resistance 1 (BCAR1)
Cat#:TP01301应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | Phospho-BCAR1 (Tyr410) Rabbit pAb |
| Cat No.: | DPA05382 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IP |
| Recommended Dilution: | WB: 1:1000 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Tyr410 of human BCAR1 |
| Calculated Molecular Weight: | 93 kDa |
| Observed Molecular Weight: | 130 kDa |
| GenBank Accession Number: | P56945 |
| Gene ID (NCBI): | 9564 |
| Synonyms: | CAS; CAS1; CASS1; CRKAS; P130Cas |
| Background: | The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017] |
| Category: | Primary Ab |
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