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查看说明书SHIP-1 Rabbit pAb
Cat#:DPA01887应用：WB,IHC,ICC/IF,FC,IP
| Product Name: | Phospho-SHIP-1 (Tyr1020) Rabbit pAb |
| Cat No.: | DPA05391 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,ICC/IF,IP |
| Recommended Dilution: | WB: 1:1000 ICC/IF: 1:50 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Tyr1020 of human SHIP-1 |
| Calculated Molecular Weight: | 133 kDa |
| Observed Molecular Weight: | 145 kDa |
| GenBank Accession Number: | Q92835 |
| Gene ID (NCBI): | 3635 |
| Synonyms: | SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship |
| Background: | This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| Category: | Primary Ab |
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