蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Phospho-HDAC5 (Ser498) Rabbit pAb
Cat#:DPA05392应用：WB
| Product Name: | Phospho-HDAC5 (Ser498) Rabbit pAb |
| Cat No.: | DPA05392 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB |
| Recommended Dilution: | WB: 1:1000 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser498 of human HDAC5 |
| Calculated Molecular Weight: | 122 kDa |
| Observed Molecular Weight: | 140 kDa |
| GenBank Accession Number: | Q9UQL6 |
| Gene ID (NCBI): | 10014 |
| Synonyms: | HD5; NY-CO-9 |
| Background: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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