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分子生物学
规格：
查看说明书Chk1 Rabbit pAb
Cat#:DPA01347应用：WB,IHC,ICC/IF,FC
| Product Name: | Phospho-Chk1 (Ser280) Rabbit pAb |
| Cat No.: | DPA05418 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IP |
| Recommended Dilution: | WB: 1:1000 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser280 of human Chk1 |
| Calculated Molecular Weight: | 54 kDa |
| Observed Molecular Weight: | 54 kDa |
| GenBank Accession Number: | O14757 |
| Gene ID (NCBI): | 1111 |
| Synonyms: | CHK1 |
| Background: | The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011] |
| Category: | Primary Ab |
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