蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书PML Protein Rabbit pAb
Cat#:DPA02016应用：WB,IHC,ICC/IF,IP
| Product Name: | Phospho-PML Protein (Ser518) Rabbit pAb |
| Cat No.: | DPA05463 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB,IHC |
| Recommended Dilution: | WB: 1:1000 IHC: 1:50 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser518 of human PML Protein |
| Calculated Molecular Weight: | 98 kDa |
| Observed Molecular Weight: | 98,117 kDa |
| GenBank Accession Number: | P29590 |
| Gene ID (NCBI): | 5371 |
| Synonyms: | MYL; RNF71; PP8675; TRIM19 |
| Background: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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