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Phospho-c-Met (Tyr1349) Rabbit pAb

Cat No.: DPA05471
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Product Name: Phospho-c-Met (Tyr1349) Rabbit pAb
Cat No.: DPA05471
Clonality: Polyclonal
Species Reactivity: Human
Tested Applications: WB,IHC,IP
Recommended Dilution: WB: 1:1000
IHC: 1:20
IP: 1:20
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Tyr1349 of human Met
Calculated Molecular Weight: 156 kDa
Observed Molecular Weight: 170140 kDa
GenBank Accession Number: P08581
Gene ID (NCBI): 4233
Synonyms: HGFR; AUTS9; RCCP2; c-Met; DFNB97
Background: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Category: Primary Ab
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