蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书MLKL Rabbit pAb
Cat#:DPA04827应用：WB,IHC
| Product Name: | Phospho-MLKL (Ser358) Rabbit pAb |
| Cat No.: | DPA05588 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IHC |
| Recommended Dilution: | WB: 1:1000 IHC: 1:50 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser358 of human MLKL |
| Calculated Molecular Weight: | 55 kDa |
| Observed Molecular Weight: | 55 kDa |
| GenBank Accession Number: | Q8NB16 |
| Gene ID (NCBI): | 197259 |
| Synonyms: | hMLKL |
| Background: | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015] |
| Category: | Primary Ab |
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