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Phospho-PRK1/PRK2/PRK3 (Thr774/Thr816/Thr718) Rabbit pAb

Cat No.: DPA05619
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Product Name: Phospho-PRK1/PRK2/PRK3 (Thr774/Thr816/Thr718) Rabbit pAb
Cat No.: DPA05619
Clonality: Polyclonal
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB,FC
Recommended Dilution: WB: 1:1000
FC: 1:20
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Thr774 of human PRK1
Calculated Molecular Weight: 104,112,99 kDa
Observed Molecular Weight: 120-140 kDa
GenBank Accession Number: Q16512
Gene ID (NCBI): 5585
Synonyms: DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA
Background: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Category: Primary Ab
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