蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书PKN Rabbit pAb
Cat#:DPA01948应用：WB,IHC,ICC/IF,IP
| Product Name: | Phospho-PRK1/PRK2/PRK3 (Thr774/Thr816/Thr718) Rabbit pAb |
| Cat No.: | DPA05619 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,FC |
| Recommended Dilution: | WB: 1:1000 FC: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Thr774 of human PRK1 |
| Calculated Molecular Weight: | 104,112,99 kDa |
| Observed Molecular Weight: | 120-140 kDa |
| GenBank Accession Number: | Q16512 |
| Gene ID (NCBI): | 5585 |
| Synonyms: | DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA |
| Background: | The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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