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查看说明书Phospho-SSH3BP1 (Tyr435) Rabbit pAb
Cat#:DPA05662应用：WB,ICC/IF,FC,IP
| Product Name: | Phospho-SSH3BP1 (Tyr435) Rabbit pAb |
| Cat No.: | DPA05662 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,ICC/IF,FC,IP |
| Recommended Dilution: | WB: 1:2000 ICC/IF: 1:50 FC: 1:20 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Tyr435 of human SSH3BP1 |
| Calculated Molecular Weight: | 55 kDa |
| Observed Molecular Weight: | 55 kDa |
| GenBank Accession Number: | Q8IZP0 |
| Gene ID (NCBI): | 10006 |
| Synonyms: | E3B1; ABI-1; ABLBP4; NAP1BP; SSH3BP; SSH3BP1 |
| Background: | This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011] |
| Category: | Primary Ab |
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