蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书p130 Rabbit pAb
Cat#:DPA04073应用：WB,IHC,FC
| Product Name: | Phospho-p130 (Thr986) Rabbit pAb |
| Cat No.: | DPA05685 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB,FC,IP |
| Recommended Dilution: | WB: 1:1000 FC: 1:50 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Thr986 of human p130 |
| Calculated Molecular Weight: | 128 kDa |
| Observed Molecular Weight: | 130 kDa |
| GenBank Accession Number: | Q08999 |
| Gene ID (NCBI): | 5934 |
| Synonyms: | Rb2; P130 |
| Background: | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Category: | Primary Ab |
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