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查看说明书Glucocorticoid Receptor Rabbit pAb
Cat#:DPA02645应用：WB,FC
| Product Name: | Phospho-Glucocorticoid Receptor (Ser226) Recombinant Rabbit mAb |
| Cat No.: | RMA03047 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IHC |
| Recommended Dilution: | WB: 1:1000 IHC: 1:100 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser226 of human Glucocorticoid Rece |
| Calculated Molecular Weight: | 86 kDa |
| Observed Molecular Weight: | 94 kDa |
| GenBank Accession Number: | P04150 |
| Gene ID (NCBI): | 2908 |
| Synonyms: | GR; GCR; GRL; GCCR; GCRST |
| Background: | This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011] |
| Category: | Primary Ab |
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