蛋白
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检测试剂盒
辅助试剂
分子生物学
规格：
查看说明书Anti- Human /Mouse /Rat /Monkey Smad2/3 Thr8 Polyclonal Antibody
Cat#:PA05871应用：WB,IHC-p,ELISA
| Product Name: | Phospho-Smad2 (Ser255) Recombinant Rabbit mAb |
| Cat No.: | RMA03081 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC, IP |
| Recommended Dilution: | WB: 1:1000 IHC: 1:20 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser255 of human Smad2 |
| Calculated Molecular Weight: | 52 kDa |
| Observed Molecular Weight: | 60 kDa |
| GenBank Accession Number: | Q15796 |
| Gene ID (NCBI): | 4087 |
| Synonyms: | JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2 |
| Background: | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] |
| Category: | Primary Ab |
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