蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书DDB1 Rabbit pAb
Cat#:DPA01063应用：WB,IHC,ICC/IF,IP
| Product Name: | DDB1 Rabbit pAb |
| Cat No.: | DPA01063 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC,ICC/IF,IP |
| Recommended Dilution: | WB: 1:2000-1:10000 IHC: 1:50 ICC/IF: 1:20 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human DDB1 |
| Calculated Molecular Weight: | 127 kDa |
| Observed Molecular Weight: | 127 kDa |
| GenBank Accession Number: | Q16531 |
| Gene ID (NCBI): | 1642 |
| Synonyms: | XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1 |
| Background: | The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012] |
| Category: | Primary Ab |
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