蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书SFPQ Rabbit pAb
Cat#:DPA01108应用：WB,IHC,ICC/IF
| Product Name: | SFPQ Rabbit pAb |
| Cat No.: | DPA01108 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC,ICC/IF |
| Recommended Dilution: | WB: 1:2000-1:10000 IHC: 1:50 ICC/IF: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human SFPQ |
| Calculated Molecular Weight: | 76 kDa |
| Observed Molecular Weight: | 100 kDa |
| GenBank Accession Number: | P23246 |
| Gene ID (NCBI): | 6421 |
| Synonyms: | PSF; POMP100; PPP1R140 |
| Background: | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. |
| Category: | Primary Ab |
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