蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书MLH1 Rabbit pAb
Cat#:DPA01215应用：WB,IHC,ICC/IF,FC,IP
| Product Name: | MLH1 Rabbit pAb |
| Cat No.: | DPA01215 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IHC,ICC/IF,FC,IP |
| Recommended Dilution: | WB: 1:1000 IHC: 1:20 ICC/IF: 1:20 FC: 1:100 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human MLH1 |
| Calculated Molecular Weight: | 85 kDa |
| Observed Molecular Weight: | 85 kDa |
| GenBank Accession Number: | P40692 |
| Gene ID (NCBI): | 4292 |
| Synonyms: | FCC2; COCA2; HNPCC; hMLH1; HNPCC2 |
| Background: | The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017] |
| Category: | Primary Ab |
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