蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Axin 2 Rabbit pAb
Cat#:DPA01258应用：WB,IHC,ICC/IF
| Product Name: | Axin 2 Rabbit pAb |
| Cat No.: | DPA01258 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC,ICC/IF |
| Recommended Dilution: | WB: 1:1000 IHC: 1:20 ICC/IF: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human Axin 2 |
| Calculated Molecular Weight: | 94 kDa |
| Observed Molecular Weight: | 94 kDa |
| GenBank Accession Number: | Q9Y2T1 |
| Gene ID (NCBI): | 8313 |
| Synonyms: | AXIL; ODCRCS |
| Background: | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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