蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Collagen IV Rabbit pAb
Cat#:DPA01445应用：IHC
| Product Name: | Collagen IV Rabbit pAb |
| Cat No.: | DPA01445 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | IHC |
| Recommended Dilution: | IHC: 1:100 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human Collagen IV |
| Calculated Molecular Weight: | 161 kDa |
| GenBank Accession Number: | P02462 |
| Gene ID (NCBI): | 1282 |
| Synonyms: | BSVD; BSVD1; RATOR; PADMAL; COL4A1s |
| Background: | This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| Category: | Primary Ab |
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