蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书PAR4 Rabbit pAb
Cat#:DPA01582应用：WB
| Product Name: | PAR4 Rabbit pAb |
| Cat No.: | DPA01582 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB |
| Recommended Dilution: | WB: 1:1000 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human PAR4 |
| Calculated Molecular Weight: | 37 kDa |
| Observed Molecular Weight: | 41 kDa |
| GenBank Accession Number: | Q96IZ0 |
| Gene ID (NCBI): | 5074 |
| Synonyms: | PAR4; Par-4 |
| Background: | This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017] |
| Category: | Primary Ab |
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