蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书DAB2 Rabbit pAb
Cat#:DPA02086应用：WB,IHC,IP
| Product Name: | DAB2 Rabbit pAb |
| Cat No.: | DPA02225 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,ICC/IF,FC,IP |
| Recommended Dilution: | WB: 1:2000 ICC/IF: 1:50 FC: 1:20 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human DAB2 |
| Calculated Molecular Weight: | 83 kDa |
| Observed Molecular Weight: | 96 kDa |
| GenBank Accession Number: | P98082 |
| Gene ID (NCBI): | 1601 |
| Synonyms: | DOC2; DOC-2 |
| Background: | This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| Category: | Primary Ab |
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