蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Recombinant Human CSTB Protein
Cat#:TP01758应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | Cystatin B Rabbit pAb |
| Cat No.: | DPA02268 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Rat |
| Tested Applications: | WB,IHC,FC |
| Recommended Dilution: | WB: 1:1000 IHC: 1:50 FC: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human Cystatin-B |
| Calculated Molecular Weight: | 11 kDa |
| Observed Molecular Weight: | 11 kDa |
| GenBank Accession Number: | P04080 |
| Gene ID (NCBI): | 1476 |
| Synonyms: | PME; ULD; CST6; EPM1; STFB; CPI-B; EPM1A |
| Background: | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. [provided by RefSeq, Jul 2016] |
| Category: | Primary Ab |
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