蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书MCM4 Rabbit pAb
Cat#:DPA02278应用：WB,FC,IP
| Product Name: | MCM4 Rabbit pAb |
| Cat No.: | DPA02278 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB,FC,IP |
| Recommended Dilution: | WB: 1:2000-1:10000 FC: 1:20-1:100 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human MCM4 |
| Calculated Molecular Weight: | 97 kDa |
| Observed Molecular Weight: | 97 kDa |
| GenBank Accession Number: | P33991 |
| Gene ID (NCBI): | 4173 |
| Synonyms: | NKCD; CDC21; CDC54; IMD54; NKGCD; hCdc21; P1-CDC21 |
| Background: | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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