蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书TRIM56 Rabbit pAb
Cat#:DPA02910应用：WB,IHC,ICC/IF,FC
| Product Name: | TRIM56 Rabbit pAb |
| Cat No.: | DPA02910 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IHC,ICC/IF,FC |
| Recommended Dilution: | WB: 1:2000-1:10000 IHC: 1:20 ICC/IF: 1:50 FC: 1:20-1:100 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human TRIM56 |
| Calculated Molecular Weight: | 82 kDa |
| Observed Molecular Weight: | 82 kDa |
| GenBank Accession Number: | Q9BRZ2 |
| Gene ID (NCBI): | 81844 |
| Synonyms: | RNF109 |
| Background: | E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). |
| Category: | Primary Ab |
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